2025
Daseul Lee, Eun Jung Na, Yumi Heo, Jinha Yu, Hwa-Jung Kim, 8-Hydroxy-2-Anilino-1, 4-Naphthoquinone Prevents Against Ferroptotic Neuronal Death and Kainate-Induced Epileptic Seizures, Pharmaceutics 2025, 17(11), 1415, doi.org/10.3390/pharmaceutics17111415
Yun A Yum, Sung Chul Jang, Seung Woo Kim, Dnyandev B Jarhad, Vikas R Aswar, Sushil Kumar Tripathi, Eun Seo Bae, Hongseok Choi, Jinha Yu, Sang Kook Lee, Lak Shin Jeong, Design and development of 5′-modified 7-substituted 4′-Thionucleosides as potent Haspin inhibitors: Synthesis and biological evaluation, Bioorganic Chemistry, 2025, 166, 109146, doi.org/10.1016/j.bioorg.2025.109146
Hyesu Oh, Hyeonhwa Lee, Jinha Yu, Lipid-conjugated nucleoside prodrugs for antiviral therapy, Bioorganic Chemistry, 2025, 165, 108935, doi.org/10.1016/j.bioorg.2025.108935
Vikas R. Aswar, Dnyandev B. Jarhad, Jiyoon Song, Jinha Yu, Lak shin Jeong, Design, Synthesis and Biological Evaluation of N6-Substituted-C2-Alkynyl-4′-Thionucleoside and 4′-Trucatedthionucleoside Derivatives as Novel A3 Adenosine Receptor Ligands, Chem Med Chem, 2025, 20(13):e202500135, doi.org/10.1002/cmdc.202500135
Minjae Kim, Jina Kim, Sushil K Tripathi, Vikas R Aswar, Vidyasagar Gaikwad, Jiyoon Song, Meehyein Kim, Jinha Yu, Tong-Shin Chang, Lak Shin Jeong, Steric influence of 4′-position substituents and C2-Hexynyl group on A3AR antagonism in truncated 4′-Thioadenosine derivatives, Bioorganic Chemistry, 2025, 159, 108359, doi.org/10.1016/j.bioorg.2025.108359
Siddhi D. Naik, Minjae Kim, Jiyoung Choi, Gibae Kim, Seung Woo Kim, Vikas R. Aswar, Sushil K. Tripathi, Vidyasagar Gaikwad, Jinha Yu*, Lak Shin Jeong*, Exploring C2 and N6 Substituent Effects on Truncated 4'-Thioadenosine Derivatives as Dual A2A and A3 Adenosine Receptor Ligands, ChemMedChem, 2025, 20(4), e202400575, DOI:10.1002/cmdc.202400575
2024
Kisu Sung, Sehwan Oh, Hong-Rae Kim, Seokhwan Hyeon, Jin-Hyun Ahn, Suyeon Kim, Vikas R. Aswar, Sushil K. Tripathi, Jinha Yu*, and Lak Shin Jeong*, Development of 4′-Oxo-MLN4924 as potential neddylation inhibitors: Design, synthesis, anti-HCMV evaluation, and molecular docking, Results in Chemistry, 2024, 11, 101765, DOI: 10.1016/j.rechem.2024.101765
Gibae Kim, Dnyandev B. Jarhad, Grim Lee, Gyudong Kim, Xiyan Hou, Jinha Yu, Chang Soo Lee, Eugene Warnick, Zhan-Guo Gao, Sang Yeop Ahn, Dongik Kwak, Kichul Park, Summer Dabin Lee, Tae-uk Park, So-young Jung, Jong Hyun Lee, Jong-Ryoul Choi, Myeongjoong Kim, Donghyun Kim, Bongtae Kim, Kenneth A. Jacobson, and Lak Shin Jeong*, Structural modification and biological evaluation of 2,8-disubstituted adenine and its nucleosides as A2A adenosine receptor antagonists: Exploring the roles of ribose at adenosine receptors, Journal of Medicinal Chemistry, 2024, 67(12), 10490-10507, DOI: 10.1021/acs.jmedchem.4c01003
Youngchai Son, Ji Su Yang, Sang Chul Shin, Seo Kyoung Park, Yeojin Kim, Jinyoung Park*, and Jinha Yu*, Structural optimization and biological evaluation of ML364 based derivatives as USP2a inhibitors, Bioorganic Chemistry, 2024, 145, 107222, DOI: 10.1016/j.bioorg.2024.107222
2023
Gibae Kim, Xiyan Hou, Woong Sub Byun, Gyudong Kim, Dnyandev B. Jarhad, Grim Lee, Young Eum Hyun, Jinha Yu, Chang Soo Lee, Shuhao Qu, Eugene Warnick, Zhan-Guo Gao, Ji Yong Kim, Seunghee Ji, Hyunwoo Shin, Jong-Ryoul Choi, Kenneth A. Jacobson, Hyuk Woo Lee, Sang Kook Lee, and Lak Shin Jeong*, Structure−Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity, Journal of Medicinal Chemistry, 2023, 66, 12249-12265, DOI: 10.1021/acs.jmedchem.3c00806
Kisu Sung, Seokhwan Hyeon, Minjae Kim, Pramod K. Sahu, Siddhi D. Naik, Vikas R. Aswar, Sushil K. Tripathi, Tong-Shin Chang, Jin-Hyun Ahn, Jinha Yu,* and Lak Shin Jeong* Design, Synthesis, and Molecular Docking Analysis of Fluorinated MLN4924 Derivatives as Antiviral Agents, Asian Journal of Organic Chemistry, 2023, e20230416
Chaebin Han, Sun Choi, Jinha Yu* DMAP and TBPP-mediated synthesis of urea-substituted nucleobases and nucleosides, Tetrahedron, 2023, 140, 133472, DOI: 10.1016/j.tet.2023.133472 0040-4020
Jinha Yu, Ji Won Kim, Girish Chandra, Noriko Saito–Tarashima, Yuhei Nogi, Masashi Ota, Noriaki Minakawa, Lak Shin Jeong,* Synthesis of oligonucleotides containing 5′-homo-4′-selenouridine derivative and its increased resistance against nuclease, Bioorganic & Medicinal Chemistry Letters, 2023, 83, 129172, DOI:10.1016/j.bmcl.2023.129172
Youngchai Son, Jaeyeal Kim, Yongchan Kim, Sung-Gil Chi, Tackhoon Kim*, Jinha Yu*, Discovery of dioxo-benzo[b]thiophene derivatives as potent YAP-TEAD interaction inhibitors for treating breast cancer, 2023, 131, 106274, DOI:10.1016/j.bioorg.2022.106274
2022
Anna Shiriaeva, Daejin Park, Gyudong Kim, Yoonji Lee, Xiyan Hou, Dnyandev B Jarhad, Gibae Kim, Jinha Yu, Young Eum Hyun, Woomi Kim, Zhan-Guo Gao, Kenneth A Jacobson, Gye Won Han, Raymond C Stevens, Lak Shin Jeong*, Sun Choi*, Vadim Cherezov*, GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor, Journal of Medicinal Chemistry, 2022, 65, 11648-11657. DOI: 10.1021/acs.jmedchem.2c00462
Sujin Park, Yujin Ahn, Yongchan Kim, Eun Joo Roh, Yoonji Lee, Chaebin Han, Hee Min Yoo*, Jinha Yu*, Design, Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives Targeting hA1 and hA3 Adenosine Receptor, Molecules, 2022, 6, 27, 4016. DOI: 10.3390/molecules27134016
Biebele Abel, Megumi Murakami, Dilip K. Tosh, Jinha Yu, Sabrina Lusvarghi, Ryan G. Campbell, Zhan-Guo Gao, Kenneth A. Jacobson*, Suresh V. Ambudkar*, Interaction of A3 adenosine receptor ligands with the human multidrug transporter ABCG2, European Journal of Medicinal Chemistry, 2022, 231, 114103, DOI: 10.1016/j.ejmech.2022.114103